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Renal inflammatory pathway mediation by miRNA: isolation and quantification of miR-103a-3p
RNA isolation and quantification of miRNAs are gaining significance as promising methods in cancer biomarker discovery. Establishing standardized protocols for collection, sample storage conditions, and the use of exogenous and endogenous controls for normalization are all critical aspects to reliably quantify miRNA levels which can be further implemented in a clinical laboratory setting. Quilun et al. at the University of
Exploring the role of cerebrospinal fluid miRNA in brain tumour diagnostics
The National Institute of Health estimates that approximately 6 in 100 000 individuals develop brain or central nervous system-related cancers each year1. Current approaches in the diagnosis of brain cancer include CT scans, MRI and tissue biopsy. However, such techniques can be limited by tumour location and heterogeneity, and in the case of tissue biopsy, its highly invasive nature. “Liquid
ASTECs: Engineered Immortals that Package a Potent Punch
Cell therapy using cardiosphere-derived cells (CDCs) is an increasingly promising treatment for acute and congenital heart muscle injuries, including myocardial infarction (MI). The therapeutic potency of CDCs has been attributed to the cargo they secrete via exosomes and other extracellular vesicles (EVs), which act to suppress inflammatory and fibrotic processes, whilst promoting cell renewal. Unfortunately, broad clinical application of CDCs
Norgen Biotek’s Stool Nucleic Acid Preservative Best-in-Class for Maintenance of Microbial Community Composition in Comparative Study
Large-scale human microbiota studies have generated key insights into a variety of disease processes, including cardiovascular disease, carcinogenesis, diabetes, hypertension, and inflammatory bowel disease. However, the utility of such studies is contingent on accurate and consistent representation of microbial communities. Stool preservatives are commonly used to prevent shifts in microbial community composition which result in bias during the period between
The Detection & Expression of Circulating miRNAs as Biomarkers Hold High Clinical Implications for Predicting Prostate Cancer Recurrence Post Radical Prostatectomy.
Currently, there is limited technology available for accurately predicting high-risk cancer biochemical recurrence (BCR). As such, there is a significant clinical need to discover non-invasive biomarkers in hopes to identify these high-risk patients and prevent unnecessary therapy and over-treatment. Researchers from Sunnybrook Research Institute aimed to identify non-invasive circulating miRNAs in patients that had previously undergone radical prostatectomy in order
Webinar 2: Comprehensive Coverage of Exosome Purification and Exosomal RNA Isolation from Different Types of Liquid Biopsies
On April 17th and 18th, Norgen Biotek presented their second webinar: “Comprehensive Coverage of Exosome Purification and Exosomal RNA Isolation from Different Type of Liquid Biopsies”. Bastien Paré – a member of the R&D team, who works extensively with liquid biopsies, exosomes, RNA purifications, and small RNA NGS – facilitated the exosomal-related webinar in French and English. Topics included exosomal
Researchers in Spain Identify Liver-Specific miRNAs Detected in Exosomes from HIV/HCV Patients
A group of researchers from the Institute of Health Carlos III (ISCIII) in Spain, presented a poster at the annual meeting for ISEV (International Society of Extracellular Vesicles) which analysed exosome RNA content for identification of new liver disease biomarkers. Using highthroughput NGS, the group identified multiple liver-specific miRNAs from plasma exosomes of patients who are coinfected with HIV and
Nature Medicine: Researchers at University of California Identify Orphan Non-Coding RNA as a Promoter of Breast Cancer Metastasis
In a systematic search to identify breast-cancer-specific small non-coding RNAs, a group of researchers has discovered a novel microRNA found to be a promoter of breast cancer metastasis. They focused on this specific set of RNAs to search for a possible source of regulators capable of moderating disease pathways. They discovered 201 previously unknown small RNAs expressed solely in breast
NORGEN NEWS
Norgen Biotek’s Stool Nucleic Acid Preservative Best-in-Class for Maintenance of Microbial Community Composition in Comparative Study
Large-scale human microbiota studies have generated key insights into a variety of disease processes, including cardiovascular disease, carcinogenesis, diabetes, hypertension, and inflammatory bowel disease. However, the utility of such studies is contingent on accurate and consistent representation of microbial communities. Stool preservatives are commonly used
The Detection & Expression of Circulating miRNAs as Biomarkers Hold High Clinical Implications for Predicting Prostate Cancer Recurrence Post Radical Prostatectomy.
Currently, there is limited technology available for accurately predicting high-risk cancer biochemical recurrence (BCR). As such, there is a significant clinical need to discover non-invasive biomarkers in hopes to identify these high-risk patients and prevent unnecessary therapy and over-treatment. Researchers from Sunnybrook Research Institute aimed
Webinar 2: Comprehensive Coverage of Exosome Purification and Exosomal RNA Isolation from Different Types of Liquid Biopsies
On April 17th and 18th, Norgen Biotek presented their second webinar: “Comprehensive Coverage of Exosome Purification and Exosomal RNA Isolation from Different Type of Liquid Biopsies”. Bastien Paré – a member of the R&D team, who works extensively with liquid biopsies, exosomes, RNA purifications, and
Researchers in Spain Identify Liver-Specific miRNAs Detected in Exosomes from HIV/HCV Patients
A group of researchers from the Institute of Health Carlos III (ISCIII) in Spain, presented a poster at the annual meeting for ISEV (International Society of Extracellular Vesicles) which analysed exosome RNA content for identification of new liver disease biomarkers. Using highthroughput NGS, the group
Nature Medicine: Researchers at University of California Identify Orphan Non-Coding RNA as a Promoter of Breast Cancer Metastasis
In a systematic search to identify breast-cancer-specific small non-coding RNAs, a group of researchers has discovered a novel microRNA found to be a promoter of breast cancer metastasis. They focused on this specific set of RNAs to search for a possible source of regulators capable
Molecular Med Tri-Con 2019
Norgen will be in San Francisco at the Molecular Med TRI-CON. Come by Booth #621 to visit with Norgen CEO Dr. Haj-Ahmad and Tom from Sales and Marketing. Details Conference: Molecular Med Tri-Con Date: March 10 – March 15, 2019 Booth: #621 Location: Moscone Center
Norgen Biotek Launches Webinar Series
On Wednesday February 20th, 2019 Norgen Biotek launched their first webinar, marking the beginning of a series of webinars scheduled for 2019. Dr. Moemen Abdalla, a senior research and development scientist with Norgen Biotek Corp., presented the first talk titled ‘Recent Advances in the Preservation
Norgen Biotek Issues Press Release: Norgen’s cf-DNA/cf-RNA Preservative Tubes Found Most Suitable for Liquid Biopsy Applications
Last week Norgen Biotek Corp. issued a press release highlighting a recent finding in a paper published in the International Journal of Medical Sciences by a group of researchers at the University Hospital of Heidelberg and the German Cancer Center. The scientists conducted a comparison
Norgen Biotek’s Plasma/Serum Cell-Free Circulating DNA Purification Kits Shown to Recover Highest Amount of Small DNA Fragments when Compared to Other Commercially Available Purification Kits
A recent study conducted by researchers at the Macquarie University in Sydney, Australia evaluated the efficiency of several commercially available kits for extracting cell-free circulating DNA from plasma samples. The study compared two spin-column based kits including the QIAmp Circulating Nucleic Acid Kit (Qiagen, Germany)
Researchers Utilize Circulating Tumor DNA to Analyze KRAS Mutations in Colorectal Cancer Patients with Liver Metastases
This past October at the European Society of Medical Oncology Congress 2018, a group of researchers from IMDL Genome Centre Bulgaria presented a poster focused on cell-free circulating tumor DNA with KRAS/EGFR mutations in metastatic colorectal cancer (mCRC) patients. The emergence of KRAS mutation during
Norgen Biotek Achieves Illumina Propel Certification as a Service Provider for Next Generation Sequencing
THOROLD, ON, Nov. 20, 2018 /PRNewswire/ – Norgen Biotek Corp., an innovative privately held Canadian biotechnology company focusing primarily on nucleic acid and protein stabilization and purification, as well as providing high quality services to the scientific community, today announced that it has become Propel-Certified through Illumina as
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Molecular Med Tri-Con 2019
Biotechnology Converges: Global Distributor Meeting 2018
Next Generation Dx Summit: August 21 – 24, 2018
